show the potential of acoustics for monitoring the drying of pharmaceutical granules 2 METHOD The fluidized-bed drying apparatus was a conical column with the dimensions given in Fig 1 The distributor was stainless steel 100 ^m mesh Four air outlets were located on the top of the column These outlets were fitted with filter cloth to prevent dust from escaping A port fitted with a 04/06/2005Monitoring Fluidized Bed Drying of Pharmaceutical Granules AAPS PharmSciTech 2010 DOI: 10 1208/s12249-010-9538-1 Aditya U Vanarase Manel Alcal Jackeline I Jerez Rozo Fernando J Muzzio Rodolfo J Romaach Real-time monitoring of drug concentration in a continuous powder mixing process using NIR spectroscopy

Real

The purpose of this study was an attempt to adapt the audible acoustic emission (AAE) sound measurement method for the on-line monitoring of the fluid-bed drying progress of pharmaceutical granules The granules were prepared by extrusion-granulation based on a formulation of 6 7 : 2 : 1 lactose–starch–crystalline

Abstract Among various methods for drying of pharmaceutical granules in the pharmaceutical industry fluidized bed drying is a frequently used method due to its high rate of moisture removal excellent performance in solids mixing and heat and mass transfer As pharmaceutical powders are typically organic materials with high resistivity they can easily be charged due to repeated collision

51 Briens L Bojarra M Monitoring Fluidized Bed Drying of Pharmaceutical Granules AAPS PharmSciTech 2010 11(4):1612-1618 52 Daniher D Briens L Tallevi A End-point detection in high-shear granulation using sound and vibration signal analysis Powder Technology 2008 181(2):130-136 53 Hansuld E Briens L McCann J Sayani A Audible acoustics in high-shear wet granulation: Application

04/06/2005Monitoring Fluidized Bed Drying of Pharmaceutical Granules AAPS PharmSciTech 2010 DOI: 10 1208/s12249-010-9538-1 Aditya U Vanarase Manel Alcal Jackeline I Jerez Rozo Fernando J Muzzio Rodolfo J Romaach Real-time monitoring of drug concentration in a continuous powder mixing process using NIR spectroscopy

Fluid Bed Dryer is the best technology in current market scenario for drying efficiently and uniformly be it powder pellets or granules The efficiency of the fluid bed dryer is time proven The design of the fluid bed dryer is very simple but effective with distribution plate playing a very effective role in drying

Investigation on drying kinetics and tribocharging

01/07/2017The fluidized bed drying apparatus is shown in Fig 1 with detailed dimensions of the product bowl presented in Fig 2 The product bowl was loaded with a batch of 3 kg wet granules As shown in Fig 1 the product bowl was fitted with a sample thief made of Teflon (PTFE) allowing to take a sample of approximately 3 g each time during the drying process

pharmaceutical and other industries as a one-step enclosed operation Because several ingredients can be mixed granulated and dried in the same vessel the technique reduces material handling and shortens process times compared with other wet granulation processes In addition to granulation for tableting the fluid-bed top-spray method produces highly dispersible granules with a

pharmaceutical industry for a long period of time [3 11] Fluid bed granulation is a key manufacturing step that allows the production of granules by spraying a binder solution over a fluidized powder The general purpose of granulation is to improve flow characteristics blend uniformity compression properties and to reduce the dust [4

Abstract Among various methods for drying of pharmaceutical granules in the pharmaceutical industry fluidized bed drying is a frequently used method due to its high rate of moisture removal excellent performance in solids mixing and heat and mass transfer As pharmaceutical powders are typically organic materials with high resistivity they can easily be charged due to repeated collision

We have varied the initial moisture content inside the pharmaceutical materials from 6% to 20% because in pharmaceutical manufacturing fluidized bed drying is generally carried out after the wet granulation step and the moisture content in the wet granules is normally in this range The impacts of air flow and air temperature on the drying process were also investigated This provides us

Fluidized bed dryer (FBD) is well known and widely used equipment in granulation area of pharmaceutical manufacturing It is used in the granulation process for drying the material to get desired moisture content in the tablet formulation granules required for perfect compression of tablets

Monitoring fluidized bed drying of pharmaceutical granules AAPS PharmSciTech 2010 11(4):1612-8 (ISSN: 1530-9932) Briens L Bojarra M Placebo granules consisting of lactose monohydrate corn starch and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities Acoustic vibration and

04/06/2005Monitoring Fluidized Bed Drying of Pharmaceutical Granules AAPS PharmSciTech 2010 DOI: 10 1208/s12249-010-9538-1 Aditya U Vanarase Manel Alcal Jackeline I Jerez Rozo Fernando J Muzzio Rodolfo J Romaach Real-time monitoring of drug concentration in a continuous powder mixing process using NIR spectroscopy

Investigation on drying kinetics and tribocharging

Abstract Among various methods for drying of pharmaceutical granules in the pharmaceutical industry fluidized bed drying is a frequently used method due to its high rate of moisture removal excellent performance in solids mixing and heat and mass transfer As pharmaceutical powders are typically organic materials with high resistivity they can easily be charged due to repeated collision

Monitoring Fluidized Bed Drying of Pharmaceutical Granules By Lauren Briens and Megan Bojarra Abstract Placebo granules consisting of lactose monohydrate corn starch and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities Acoustic vibration and pressure data obtained over the

Fluidized bed dryers are used in drying of various materials such as powders tablets granules coals fertilizers plastic materials This process is being used in granulation of pharmaceutical powders Fluidized bed coaters are used widely for coating of powders granules tablets pellets beads held in suspension by column of air

51 Briens L Bojarra M Monitoring Fluidized Bed Drying of Pharmaceutical Granules AAPS PharmSciTech 2010 11(4):1612-1618 52 Daniher D Briens L Tallevi A End-point detection in high-shear granulation using sound and vibration signal analysis Powder Technology 2008 181(2):130-136 53 Hansuld E Briens L McCann J Sayani A Audible acoustics in high-shear wet granulation: Application

09/11/2010Fluidized bed drying experiments were carried out with placebo granules over a range of superficial gas velocities Passive acoustic and vibration monitoring techniques were investigated for monitoring drying and compared to more traditional monitoring methods of granule moisture content temperature humidity and pressure measurements

Energy analysis of a fluidized‐bed drying system is undertaken to optimize the fluidized‐bed drying conditions for large wet particles (Group D) using energy models Three critical factors the inlet air temperature the fluidization velocity and the initial moisture contents of the material (e g wheat) are studied to determine their effects on the overall energy efficiency to optimize

02/03/2015The pharmaceutical manufacturing platforms of fluid-bed granulation and milling are widely used to modify particle size However the adoption of process analytical technology to monitor and control these processes is difficult because of their dynamic nature This study examines the efficacy of a particle characterizing technology to capture particle images under dynamic conditions and to

This observation is to be expected when typical pharmaceutical fluid-bed granulators and milling considering the removal of moisture and granule-granule environments in addition to accurately measuring samples attrition during the fluidized bed drying phase All of the in an at-line benchtop set-up information presented in Figures 3a–3c could be used to develop model and control fluid-bed