Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for Enhanced Solubility and Dissolution When fabricating the PC-based solid dispersion we employed mesoporous microparticles as an adsorbent and disintegrants to improve the sticky nature of PC and dissolution of aprepitant respectively Dec 31 2014Solid dispersions have been considered as one of the most promising approaches to enhance the solubility dissolution and subsequent oral bioavailability of poorly soluble drugs through various techniques (1 6) Typically solid dispersions refer to a group of solid products consisting of two different components (7 8)

CiteSeerX — Enhanced Dissolution Rate of Atorvastatin

Abstract The solid dispersion was defined as the dispersion of one or more active ingredients in an inert carrier or matrix The purpose of the study was to improve the physicochemical properties of Atorvastatin like solubility dissolution properties and stability of poorly soluble drug by forming dispersion with Poly Ethylene Glycol (PEG) 6000 as water soluble carrier

Curcumin (CUR) is highly lipophilic drug that shows degradation at alkaline pH which restricts its oral bioavailability The aim of the present study was to enhance the oral bioavailability of CUR by increasing its solubility and dissolution rate

Objective: With the aim to enhance the dissolution rate and oral bioavailability of NRG solid dispersion technique has been applied using Soluplus as carrier Methods: Solid dispersions of NRG were prepared by solvent evaporation and kneading methods using various ratios (1:4 3:7 2:3 and 1:1) of NRG:Carrier Characterization of the

In recent years hot-melt extrusion (HME) has been shown to be a promising pharmaceutical technology to produce solid dispersions with enhanced oral bioavailabilities of poorly soluble drugs [22–24] HME is an efficient technology for producing solid molecular dispersions and there are various solid dispersion systems as pharmaceutical

Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole with Pluronic F127 Bożena Karolewicz1* Maciej Gajda1 Artur Owczarek1 Janusz Pluta1 and Agata F127 as a carrier of solid dispersions can lead to an enhanced solubilization of poorly water-soluble drugs e g ketoconazole [13 14] and

Enhanced Dissolution of Luteolin by Solid Dispersion

Luteolin (LT) is a poorly soluble bioactive compound that suffered bioavailability problems after oral administration Hence the aim of the proposed research work was to formulate and investigate various solid dispersions (SDs) of LT in order to enhance its dissolution and bioactivity LT-SD was prepared using polyethylene glycol 4000 (PEG 4000) as a carrier at the

Solid dispersions were prepared to increase the dissolution rate of biphenyl dimethyl dicarboxylate (DDB) using water-soluble carriers such as povidone copolyvidone TEX$2-hydroxypropyl-{beta}-cyclodextrin (HPCD)$/TEX sodium salicylate or sodium benzoate by solvent evaporation method Solid dispersions were characterized by infrared spectrometry

The present study aimed to increase the in vitro dissolution rate of lacidipine a poorly water-soluble drug by formulating amorphous solid dispersions (ASDs) using hot-melt extrusion (HME) Differential scanning calorimetry powder X-ray diffraction polarized light microscopy and Fourier transform infrared were used to characterize the optimal formulations and evaluate the

reduced effective surface area for dissolution But solid dispersion is the mainly promising method to formulators because of its simplicity of preparation ease of optimization and reproducibility (Chiou et al 1971 Goldberg et al 1966 Leuner et al 2000) The term 'solid dispersion' has been employed to describe a family

Objectives Nateglinide an Antidiabetic drug (BCS II ) shows pH‐dependent solubility and variable bioavailability The purpose of study was to increase dissolution and bioavailability of Nateglinide by development of its microenvironmental pH‐regulated ternary solid dispersion

The PRX-solid dispersion with ternary system were prepared using a melting method • The SD1 improved the dissolution (%) compared to that of Feldene in different dissolution medium • In vitro anti-inflammation effects of SD1 showed improved compared to Feldene • The SD1 has a good stability for 12 months (20 5 0 C RH 50-60%)

Fenofibrate (FF) is an anti-hyperlipidaemic drug belonging to BCS class-II (low solubility high permeability) Its bioavailability is limited by the dissolution rate This study was aimed to enhance the rate of dissolution of poorly water soluble drug FF Initially solid dispersions of fenofibrate (SDFs) were formulated with Carplex-80 or PEG-4000 or in combination at various

Solid dispersion formulations of megestrol acetate with copovidone for enhanced dissolution and oral bioavailability [Soon Wook Hong Bong Sang Lee Su Jun Park Hong Ryeol Jeon Ki Young Moon Mean Hyung Kang Sang Han Park Sung-Up Choi Woo Heon Song Jaehwi Lee Young Wook Choi] PMID 21468924

SOLID DISPERSION

ADVANTAGES OF SOLID DISPERSION • Solid dispersion results in particles with reduced particle size and thus the surface area are improved and increased dissolution rate is attained Hence bioavailability is increased [4] • The carrier used in the solid dispersion plays a major role in improving the wettability of the particles

Solid Molecular Dispersions of Itraconazole for Enhanced Dissolution and Controlled Drug Delivery Liu Hong Master of Science 2009 Graduate Department of Pharmaceutical Sciences University of Toronto The purpose of this study was to investigate the formation of solid molecular dispersions

Solid dispersion Solid dispersions are one of the most successful strategies to improve drug release of poorly soluble drugs Sekiguchi and Obi were the first to describe on solid dispersions in 1961 Solid dispersion is one of the important strategies to tackle dissolution-rate-limited oral absorption of poorly soluble compounds

The PRX-solid dispersion with ternary system were prepared using a melting method • The SD1 improved the dissolution (%) compared to that of Feldene in different dissolution medium • In vitro anti-inflammation effects of SD1 showed improved compared to Feldene • The SD1 has a good stability for 12 months (20 5 0 C RH 50-60%)

T1 - Microwave Processed Solid Dispersions for Enhanced Dissolution of Gemfibrozil using non-Ordered Mesoporous Silica AU - Hussain Talib AU - Waters Laura J AU - Parkes Gareth M B AU - Shahzad Yasser N1 - Not OA compliant - no AAM on ePrints PY - 2017/5/5 Y1 -

Amongst them is the solid dispersion of one or more active ingredients in inert carriers at solid state prepared by fusion solvent or solvent-fusion methods (Damian et al 2000) In solid dispersions the particle size of the drugs was reduced and the wettability and the dispersibility of the drugs were enhanced

Mefenamic acid a BCS class II drug displays high permeability and low solubility thereby exhibiting a poor dissolution profile Hence to improve the solubility and dissolution rate of Mefenamic acid Hot Melt Extrusion (HME) technique was employed The amorphous solid dispersion matrix exhibited enhanced dissolution with desired release characteristics

Dec 31 2014Solid dispersions have been considered as one of the most promising approaches to enhance the solubility dissolution and subsequent oral bioavailability of poorly soluble drugs through various techniques (1 6) Typically solid dispersions refer to a group of solid products consisting of two different components (7 8)

Title:Enhanced Dissolution Profile and Antihyperlipedimic Activity of Simvastatin by Solid Dispersion with Pluronic F68 VOLUME: 3 ISSUE: 2 Author(s):Amit R Tapas Vikas P Ingle Pravin S Kawtikwar and Dinesh M Sakarkar Affiliation:Department of Pharmaceutical Chemistry Sudhakarrao Naik Institute of Pharmacy Nagpur road Pusad–445204 Yavatmal

also confirmed by FTIR Solid dispersions of piroxicam were prepared using polyvinylpyrrolidone K-30 by solvent method The dissolution of drug in solid dispersion was dependent on drug to PVP ratio The drug: PVP in 1:4 ratio solid dispersion gave highest dissolution rate of about a 38-fold higher than that of pure drug [20]

molecules Article Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility Dissolution and Bioavailability in Rats Hyun-Jong Cho 1 † Jun-Pil Jee 2 † Ji-Ye Kang 3 Dong-Yeop Shin 4 Han-Gon Choi 5 Han-Joo Maeng 6 * and Kwan Hyung Cho 3 * 1 College of Pharmacy Kangwon National University 1 Kangwondaehak-gil Chuncheon 24341